pI: 8.9306 |
Length (AA): 298 |
MW (Da): 31931 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 297 | 4cjx (A) | 1 | 297 | 99.99 | 0 | 1 | 2.21464 | -1.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126671)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G50480 | Formate--tetrahydrofolate ligase |
Arabidopsis thaliana | AT3G12290 | amino acid dehydrogenase family protein |
Arabidopsis thaliana | AT4G00620 | Amino acid dehydrogenase family protein |
Candida albicans | CaO19.2364 | likely C1-tetrahydrofolate synthase similar to S. cerevisiae ADE3 (YGR204W) involved in purine base and histidine biosynthesis |
Candida albicans | CaO19.7534 | Mitochondrial C1-tetrahydroflate synthase |
Candida albicans | CaO19.9900 | likely C1-tetrahydrofolate synthase similar to S. cerevisiae ADE3 (YGR204W) involved in purine base and histidine biosynthesis |
Caenorhabditis elegans | CELE_K07E3.3 | Protein DAO-3 |
Caenorhabditis elegans | CELE_K07E3.4 | Protein K07E3.4, isoform A |
Chlamydia trachomatis | CT_078 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase |
Dictyostelium discoideum | DDB_G0290397 | formate-dihydrofolate ligase |
Dictyostelium discoideum | DDB_G0283121 | methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase |
Drosophila melanogaster | Dmel_CG4067 | pugilist |
Drosophila melanogaster | Dmel_CG18466 | NAD-dependent methylenetetrahydrofolate dehydrogenase |
Escherichia coli | b0529 | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase |
Echinococcus granulosus | EgrG_001195300 | methylenetetrahydrofolate dehydrogenase |
Echinococcus multilocularis | EmuJ_001195300 | methylenetetrahydrofolate dehydrogenase |
Homo sapiens | ENSG00000100714 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate syn |
Homo sapiens | ENSG00000120254 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
Homo sapiens | 10797 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
Homo sapiens | ENSG00000163738 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like |
Leishmania braziliensis | LbrM.26.0350 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Leishmania braziliensis | LbrM.30.2550 | formate--tetrahydrofolate ligase |
Leishmania donovani | LdBPK_260310.1 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Leishmania donovani | LdBPK_302590.1 | formate--tetrahydrofolate ligase |
Leishmania infantum | LinJ.30.2590 | formate--tetrahydrofolate ligase |
Leishmania infantum | LinJ.26.0310 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Leishmania major | LmjF.30.2600 | formate--tetrahydrofolate ligase |
Leishmania major | LmjF.26.0320 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Leishmania mexicana | LmxM.26.0320 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Leishmania mexicana | LmxM.29.2600 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Mycobacterium leprae | ML0674 | Probable bifunctional protein fold: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase FolD |
Mus musculus | ENSMUSG00000005667 | methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase |
Mus musculus | ENSMUSG00000040675 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
Mus musculus | ENSMUSG00000021048 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synth |
Mus musculus | ENSMUSG00000029376 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like |
Mycobacterium tuberculosis | Rv3356c | Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase |
Mycobacterium ulcerans | MUL_1428 | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase |
Oryza sativa | 4347204 | Os09g0446800 |
Oryza sativa | 4328117 | Os02g0120900 |
Oryza sativa | 4337829 | Os05g0150800 |
Saccharomyces cerevisiae | YGR204W | trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase AD |
Saccharomyces cerevisiae | YBR084W | trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MI |
Schistosoma japonicum | Sjp_0024520 | ko:K00288 methylenetetrahydrofolate dehydrogenase (NADP+) [EC1.5.1.5], putative |
Schistosoma mansoni | Smp_147650 | formate-tetrahydrofolate ligase |
Schmidtea mediterranea | mk4.001298.09 | C-1-tetrahydrofolate synthase, cytoplasmic |
Schmidtea mediterranea | mk4.001298.06 | |
Schmidtea mediterranea | mk4.001298.08 | |
Schmidtea mediterranea | mk4.038149.03 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
Schmidtea mediterranea | mk4.007154.02 | C-1-tetrahydrofolate synthase, cytoplasmic |
Trypanosoma brucei gambiense | Tbg972.7.1600 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Trypanosoma brucei | Tb927.7.1600 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Trypanosoma congolense | TcIL3000_7_1130 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Trypanosoma cruzi | TcCLB.511517.60 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Trypanosoma cruzi | TcCLB.511741.50 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Trypanosoma cruzi | TcCLB.509509.20 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Trypanosoma cruzi | TcCLB.508207.240 | C-1-tetrahydrofolate synthase, cytoplasmic, putative |
Treponema pallidum | TP0732 | methylenetetrahydrofolate dehydrogenase (folD) |
Wolbachia endosymbiont of Brugia malayi | Wbm0073 | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1600 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1600 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1600 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1600 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0529 | Escherichia coli | essential | goodall |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | Compounds | References |
1 literature reference was collected for this gene.